Hedgehog信号通路与肿瘤的关系研究进展.pdf

·808·顾红兵，等Hedgehog信号通路与肿瘤的关系研究进展

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Hedgehog信号通路与肿瘤的关系研究进展

顾红兵，李继坤

Hedgehogsignalingpathwayincancer

GUHang—bing，LIJi—kun
DepartmentofGeneralSurgery，ShanghaifiaotongUniversityAfiliatedFirstPeople'sHospital，Shanghai200080，China．
【Abstract】Hedgehog(Hh)signalingpathwayplaysacrucialroleinvertebrateembryogenesisbycontrollingcelldif-
ferentiation，bodypatterningandorgandevelopment．Itisalsobecomingincreasinglyclearthatthispathwaycanhave

acmcialroleintumorigenesis．Recently，aseriesofresearcheshaveshownthatuncontrolledactivationofHedgehog

signalingpathwayinvolvedintheformationandmaintenanceofseveraltypesofcancer．Therefore，thecomponentsof

Hhsignalingcascademayprovideasetofdmgtargets，whichcouldbeimplementedintonovelco