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7.支气管哮喘(双语)WhatIsAsthma? EpidemiologyImpactOfAsthmaOnPatientsDidYouKnow..WhatCausesAsthma?WhatCausesAsthmaTriggersandIrritantsCommonAllergens(Triggers) CommonIrritants(Triggers)Airway HyperresponsivenessVirusescauseasthmaexacerbations RVscause~60%ofvirus-inducedexacerbationsofasthma RVsdirectlyinfectthebronchialairways Theresponsetoviralinfectionisshapedbythehost’santiviralresponseNakano,Y.etal.Chest2002;122:271S-a-275S-aTheAllergicReactionTheAsthmaCascadeMediatorPhasesTheEndResultsOfTheCascade NormalBronchioleInflamedBronchiole withMucus AirwayObstructionRemodelingPhasesVignola,A.M.etal.Chest2003;123:417S-a-422S-aIncreasedthicknessofthebasementmembrane,andenhancedandabnormaldepositionofcollageninthebronchialsubmucosaALotGoingOnBeneathTheSurfaceCommonSymptomsOfAsthmaEarlySignsOfAnAsthma“Episode”MeasuresOfAssessmentAndMonitoringInitialAssessment&DiagnosisofAsthmaMethodsforEstablishingDiagnosisDiagnosisofasthmaAsthmaLungAssessmentSpirometryIsAirflowObstructionAtLeastPartiallyReversible?PeakExpiratoryFlowVariability PeakFlowMetersDifferentialdiagnosisofasthmaAsthmaSeverityLevelsAsthmaSeverityLevelsBySymptomsMildIntermittentMildPersistentModeratePersistentSeverePersistentGoalsOfAsthmaTherapyGoalsOfAsthmaTherapyContinued… StepwiseApproachTo Asthma TherapyBronchodilators Relaxingbronchialsmoothmuscletoopenuptheairway. Anti-inflammatoryagents Inhibitingthedevelopmentofairwayinflammationandstoppingongoinginflammation. Incombination,treatandpreventreversibleairwayobstructionandairwayhyperresponsiveness,relievethesymptomanddecreasetheexacerbation.Long-termcontrolmedication(Controller) Corticosteriods Cromolyn/nedocromil Longactingb2agonists(LABA) Leukotrienemodifier Quickreliefmedication(Rescuer) Short-actingb2agonists Theophylline Anticholinergics SystemicCorticosteriodsStepwisemanagementofasthmainadultsStepwisemanagementofasthmainadultsStepwisemanagementofasthmainadultsStepwisemanagementofasthmainadultsStepwisemanagementofasthmainadultsStepwisemanagementofasthmain

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