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Takentogetherourdataprovidenewmechanisticinsightsintopossibleendogenoussignalingmetastaticsignalingpathwaysinvolvedinmaintainingproliferationandmigrationofbreastcancercells.Wesoughttodeterminewhetherseliciclib(CYC202R-roscovitine)couldincreasetheantitumoreffectsofdoxorubicinwithnoincreaseintoxicityinanMCF7breastcancerxenograftmodel.MIB1(ki67)immunohistochemistrydemonstratedreducedproliferationwithtreatment.(用于ki67方面)SurvivinembodiesthesepropertiesandMoreoverinpre-clinicalbladdertumormodelsinhibitionofSurvivinexpressionand/orfunctionhasbeenshowntoimpedetumorcellproliferationandmarkedlyinducespontaneousorchemotherapyinducedapoptosisTheefficacyofmainstaycancertherapiescytotoxicsandradiationhasreachedaplateauinthetreatmentofmanycancersandthereisanurgentsensethatimprovementsmustnowcomefromfreshapproaches.Medianagewas62yearswitharangeof40-74years.splicevariantsmightfunctionineffectasdominantnegativessothattheirexpressionmightconcurrentwithsurvivin.ThereisahypothesisthatTheabsenceofinvivodataonthispointhasnowbeenremediedwithapaperinthisissueoftheJCIbyAltieriandcolleagues.Thusthisraisesaninterestingquestionwhether...raisingthepossibilitythatmostifnotalltumorsexpress...Thelevelsofp21andp27increasedaftertreatmentwithdoxorubicinorseliciclibaloneorincombinationcomparedtountreatedcontrols.Incontrastitisabundantlyexpressedinawidevarietyofmalignanttissues.Onthecontrary...BycontrastagoodtitlewillattracttherelevantresearchersandincreasethenumberofcitationsyoureceiveWehavefoundthatthehumanbreastcancercellsMCF-7/AdroverexpressnotonlyP-gpbutalsoXIAPandSurvivinandshowedhighresistancetochemotherapeuticdrugsdoxorubicindocetaxelandvincristineincontrasttotheirparentalcellsKBandMCF-7.Survivinisaberrantlyexpresse