可溶性人白细胞抗原--G在子宫腺肌病患者血清中的表达及临床意义-豆柴文库

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可溶性人白细胞抗原--G在子宫腺肌病患者血清中的表达及临床意义
Title:ExpressionandClinicalSignificanceofSolubleHumanLeukocyteAntigen-GinPatientswithEndometriosis
Abstract:
Endometriosisisacommongynecologicaldisordercharacterizedbythepresenceofendometrial-liketissueoutsidetheuterinecavity.Theetiologyandpathogenesisofendometriosisremainpoorlyunderstood.SolubleHumanLeukocyteAntigen-G(sHLA-G)isanon-classicalHLAclassImoleculewithimmunosuppressiveproperties.ThisstudyaimstoinvestigatetheexpressionofsHLA-Gintheserumofpatientswithendometriosisandexploreitsclinicalsignificance.
Introduction:
Endometriosisaffectsmillionsofwomenworldwideandisassociatedwithsignificantpain,infertility,andreducedqualityoflife.Althoughseveraltheorieshavebeenproposed,includingretrogrademenstruation,immunedysfunction,geneticpredisposition,andhormonalimbalances,theexactcauseofendometriosisremainselusive.Emergingevidencesuggeststhatimmunologicalfactorsplayacrucialroleinthedevelopmentandprogressionofendometriosis.sHLA-Ghasbeenimplicatedinimmunemodulationandtoleranceduringpregnancyandvariouspathologicalconditions.However,itsroleinendometriosisremainsunclear.
Methods:
Atotalof100patientsdiagnosedwithendometriosisand100healthycontrolswereenrolledinthisstudy.SerumsampleswerecollectedandanalyzedforsHLA-Gexpressionbyenzyme-linkedimmunosorbentassay(ELISA).Clinicaldataincludingage,stageofdisease,painscores,andfertilitystatuswererecordedandcorrelatedwithsHLA-Glevels.
Results:
TheresultsrevealedsignificantlyhigherlevelsofsHLA-Gintheserumofpatientswithendometriosiscomparedtohealthycontrols(p<0.001).Moreover,sHLA-Glevelswerepositivelycorrelatedwithdiseasestage(p<0.01)andpainscores(p<0.05).However,nosignificantassociationwasfoundbetweensHLA-Glevelsandfertilitystatus.
Discussion:
TheoverexpressionofsHLA-Ginendometriosispatientssuggestsitspotentialroleinthepathogenesisofthedisease.sHLA-GcanactasanimmunemodulatorbysuppressingcytotoxicTcellactivity,naturalkillercellfunction,andpro-inflammatorycytokineproduction.Thisimmunosuppressiveeffectmaycontribut