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NuclearMedicineFisson/ReactorProducts	CyclotronProductsDefinitionofRadiopharmaceuticalIdealRadiopharmaceuticalforImaging-FactorstoConsiderIdealPhysicalCharacteristicsofImagingRadiopharmaceuticalRadioactiveDecayProcessesDiagnosticNuclearMedicineAnatomicvs.PhysiologicImagingHowdoesPhysiologicImagingWork?Anatomyvs.PhysiologyGammaCameraGammaCameraConsistsof…SodiumIodideDetectorSodiumIodideDetector,cont’d...CollimatorGammaCameraBasics*GEWholeBodyGammaCameraSPECTImagingMo-99/Tc-99mGeneratorColumnChromatographyCardiacInfarction

201TlClRest
99mTc-Sestamibi
StressTestCardiacIschemia

201TlClRest
99mTc-Sestamibi
StressTest(MDP)NormalCanineBoneScanRibMetastasis11-yearoldboywithaone
monthhistoryofrightknee
pain

Increaseactivityintheright
tibia

Diagnosis:OsteosarcomaMetastaticProstateCarcinoma

Imaging

99mTc-HDPPrincipleofPETImaging[18F]Fluorodeoxyglucose(FDG)PETTherapeuticNuclearMedicineFissionproductsusefulinnuclearmedicineinclude:
99Mo,131I,133Xe,137Csand90SrDifferentiated
Thyroid
Carcinoma

5mCiNa131I

Imaging
TreatmentPlanning

48hp.i.Differentiated
Thyroid
Carcinoma

Therapy

105mCiNa131I

27hp.i.DifferentiatedThyroidCarcinoma
PostSurgicalResection
Therapy
57CoFloodSource+105mCiNa131IDifferentiatedThyroidCarcinoma
201TlCland99mTc-SestamibiImaging
4monthsafterNa131ITherapyCanineOsteosarcomaStoryofQuadraMetTM--IOneofOurFirstPatientsBoneScansofCaninePatientResultsofClinicalTrialof153Sm-EDTMPinCanineOsteosarcomaStoryofQuadraMet™--II153Sm-EDTMP[QuadraMet]ExperimentalNuclearMedicineTargetingvector(e.g.,mAb,peptidehormone,smallmolecule,etc.)
Radionuclide(e.g.,diagnostic–99mTc,111In,etc.;therapeutic–188Re,90Y,177Lu,etc.)
Bifunctionalchelatingagent(BCA)
Linkerorspacer
Hypothesis1ReceptorTargetingforMolecularImagingandTherapyInternalizingvs.Non-internalizingReceptorsPeptideNucleicAcidCellularDeliveryofPNADOTA-Tyr3-OctreotatePNAandPeptideConjugatesMicroSPECT/CTUsing111In-labeledPNAandPeptideConjugates(1h,48h)Bcl-2mRNAExpressionLevelsinMec-1andRamosCellsMicroSPECT/CTUsing111In-DOT