31DrugsUsedInGastrointestinalDiseases教学幻灯片课件-豆柴文库

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Chapter31DrugsUsedInGastrointestinalDiseases§1DrugsusedinpepticulcerⅠ.Antacids1.3adversereaction:Cimetidine(西咪替丁;甲氰咪胍):
400mgbid4W→80%healing
Ranitidine(雷尼替丁)
1)Antisecretiveeffectis10timesthatofCimetidine.
2)Lesseffectonhepaticmicrosomalmetabolismsystem.
3)LongerdurationandlessantiandrogeniceffectFamotidine(法莫替丁),Nizatidine(尼扎替丁):
1)Antisecretiveeffectis30timesthatofCimetidine.
2)Havenoeffectonhepaticmicrosomalmetabolismsystem.
Ebrotidine(乙溴替丁):
1)↑ExpressionofEGFandPDGF→stimulateproliferationofepithelium
2)increasemucussecretionM1-Rantagonist:Pirenzepin(哌仑西平)MechanismofactionClinicaluses:superiortoH2-Rantagonists.

Adversereactions:
1)inhibitsgastricsecretion→overgrowthofbacteria.
2)hypergastrinemia(高胃泌素血症).4.gastrin-receptorantagonists:proglumide(丙谷胺)2.sucralfate(硫糖铝)mechanismofaction:
4)increaseprostaglandinsynthesis.

5)antimicrobialactivityagainstHpylori
clinicaluse:
whencombinedwithantibiotics(metronidazoleandtetracycline),ulcerhealingratesofupto98%havebeenseen.Ⅳ.Antibacterialagents§3antiemeticdrugs2.dopamineantagonists:Domperidone(多潘立酮,吗丁林)§4laxatives