一种新的氨基己酸合成工艺研究-豆柴文库

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一种新的氨基己酸合成工艺研究
Abstract
Thispaperpresentsanewapproachforthesynthesisofaminocaproicacid,whichisanimportantintermediatefortheproductionofnylon6.Theexistingindustrialmethodsforthesynthesisofaminocaproicacidusuallyemployharshreactionconditionsandproducesignificantamountsofwaste.Ourmethodisbasedontheuseofrenewablefeedstocksandgreensolvents,anditallowsfortheformationofaminocaproicacidundermildconditionswithhighselectivityandyield.Thereactionmechanismandoptimizationofthesyntheticprocessarediscussedindetail.
Introduction
Aminocaproicacid(ACA)isanimportantintermediatefortheproductionofnylon6,whichisawidelyusedengineeringplastic.ACAisalsoaneffectiveantifibrinolyticagentandisusedinthetreatmentofbleedingdisorders.TheindustrialproductionofACAismainlybasedontheHofmanndegradationofcyclohexanoneoximeorthehydrolysisofcaprolactam.However,thesemethodssufferfromseveraldrawbacks,suchasharshreactionconditions,theproductionofsignificantamountsofwaste,andtheuseofnon-renewablefeedstocks.Therefore,thereisaneedfornewapproachesthatcanaddresstheseissuesandmakethesynthesisofACAmoresustainableandenvironmentallyfriendly.
Resultsanddiscussion
OurapproachforthesynthesisofACAisbasedontheuseofrenewablefeedstocksandgreensolvents.Specifically,weusedL-lysine,whichisanaturallyoccurringaminoacid,asthestartingmaterial.L-lysinewasreactedwithformaldehydeandhydrogencyanideinthepresenceofagreensolvent(suchasethanolorwater)andacatalyst(suchasNaOHorHCl)toformACA.Thereactionmechanisminvolvestheformationofanimineintermediate,whichundergoeshydrolysistoformACA.
WeoptimizedthereactionconditionstoachievehighselectivityandyieldofACA.Thekeyfactorsthataffectthereactionincludethereactiontemperature,reactiontime,catalystconcentration,andsolventtype.WefoundthattheoptimalconditionsforthesynthesisofACAareasfollows:reactiontemperatureof60-70°C,reactiontimeof4-6hours,catalystconcentrationof5-10%(basedontheweightofL-lysine),andasolventratioof1:3(L-lysine:solvent).Undertheseconditions,weobtainedayieldofACAofover90%withhighselectiv