一种新型的标准二次规划方法实现固定射野调强放疗的角度优化（英文）-豆柴文库

您所在位置：网站首页 / 一种新型的标准二次规划方法实现固定射野调强放疗的角度优化（英文）.docx / 文档详情

在线预览结束，喜欢就下载吧，查找使用更方便

5 金币

下载文档

/ 2

下载提示

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

文本预览

一种新型的标准二次规划方法实现固定射野调强放疗的角度优化（英文）
Title:ANovelStandardSecond-OrderProgrammingApproachforAngleOptimizationinFixed-FieldIntensity-ModulatedRadiationTherapy
Abstract:
Fixed-fieldintensity-modulatedradiationtherapy(IMRT)isapowerfultechniqueusedincancertreatmentthatallowsforprecisedosedeliverywhilesparinghealthytissues.OnecrucialstepintheplanningprocessofIMRTisangleoptimization,wheretheoptimalsetoftreatmentanglesisdeterminedtomaximizetheradiationdosetothetumortargetandsimultaneouslyminimizethedosetocriticalstructures.Inthispaper,weproposeanovelstandardsecond-orderprogramming(SSOP)approachforangleoptimizationinfixed-fieldIMRT.Theproposedmethodaimstoaddressthechallengesassociatedwithconventionaloptimizationtechniquesandprovideimprovedresults.
Introduction:
Fixed-fieldintensity-modulatedradiationtherapy(IMRT)hasgainedpopularityinrecentyearsduetoitsabilitytopreciselyshapetheradiationdosedistributioninthetargetarea.AngleoptimizationplaysacrucialroleinthesuccessofIMRT,asitdeterminesthearrangementoftreatmentbeamsaroundthepatient.Theobjectiveofangleoptimizationistofindtheoptimalsetofanglesthatmaximizesthedosetothetumorwhileminimizingthedosetocriticalstructures.Conventionaloptimizationtechniques,suchaslinearprogrammingandsimulatedannealing,havebeenusedforangleoptimization,buttheyoftensufferfromlimitationsintermsofcomputationalefficiencyandsuboptimalsolutions.Hence,theneedforanewapproach.
Methods:
Theproposedstandardsecond-orderprogramming(SSOP)approachcombinestheadvantagesofconvexoptimizationandsecond-orderconeprogrammingtosolvetheangleoptimizationprobleminfixed-fieldIMRT.IntheSSOPformulation,theobjectivefunctionistomaximizetheradiationdosetothetumortarget,whiletheconstraintsensurethatthedosestocriticalstructuresarekeptbelowcertainpredefinedthresholds.TheSSOPapproachallowsfortheinclusionofadditionalconstraints,suchasdose-volumehistogramconstraints,tofurthercustomizetheoptimizationprocess.
Results:
ToassesstheperformanceoftheSSOPapproach,asetofpatientcasesfromvariouscancertypeswere