样品预处理与实时直接分析质谱的联用技术及应用（英文）-豆柴文库

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样品预处理与实时直接分析质谱的联用技术及应用（英文）
Title:IntegrationofSamplePreprocessingandReal-timeDirectAnalysisMassSpectrometry:TechniquesandApplications
Abstract:
Samplepreprocessingplaysacrucialroleinenhancingthesensitivity,selectivity,andreliabilityofmassspectrometry(MS)analysis.Althoughtraditionalsamplepreparationmethodsarewidelyused,theyofteninvolvetime-consumingandlabor-intensiveprocesses,resultinginpotentialsampledegradation,contamination,andthelossofvolatilecompounds.Toovercomethesechallenges,theintegrationofsamplepreprocessingwithreal-timedirectanalysismassspectrometry(DART-MS)hasemergedasapromisingapproach.Thisreviewsummarizestherecentadvancesinthedevelopment,techniques,andapplicationsofthecombinedapproach,highlightingitspotentialinvariousfields,suchasenvironmentalanalysis,foodsafety,andclinicaldiagnosis.
1.Introduction:
Massspectrometryhasbecomeanindispensabletoolinanalyticalchemistryduetoitsexceptionalsensitivity,specificity,andabilitytoanalyzeawiderangeofcompounds.However,effectivesamplepreparationisoftenrequiredtoenhancetheanalysis,improvesensitivity,andmitigatematrixinterferences.Traditionalsamplepreprocessingtechniques,includingextraction,purification,andderivatization,aretime-consumingandcanresultinsamplelossordegradation.Theintegrationofsamplepreprocessingwithreal-timedirectanalysisMSprovidesasolutiontotheselimitations,enablingrapidandrobustanalysiswithouttheneedforcomplexsamplepreparation.
2.TechniquesforSamplePreprocessingandDART-MS:
2.1Solvent-AssistedDirectAnalysis:TheadditionofasolventduringDART-MSanalysisenhancesthedesorptionefficiencyofanalytes,facilitatestheirionization,andreducesmatrixeffects.Varioussolvent-assistedtechniques,suchasliquidmicrojunctionsurfacesampling,liquidextractionsurfaceanalysis,andliquid-phasemicroextraction,havebeendevelopedandsuccessfullyappliedtodifferentsampletypes.
2.2Solid-PhaseMicroextractionCoupledwithDART-MS:Solid-phasemicroextractionisasamplepreprocessingtechniquethatenablestheextractionandpreconcentrationofanalytesfromcomplexmat