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水产品中过敏原精氨酸激酶研究进展 Title:ProgressintheResearchonAllergenicHistidineKinaseinAquaticProducts Abstract: Aquaticproductshavebecomeanimportantsourceofnutritionformanypeopleworldwide.However,allergicreactionstocertaincomponentsintheseproducts,suchasfishandshellfish,havebecomeasignificantconcern.Theallergenichistidinekinase,alsoknownasATP-bindingcassettetransporter(ABCtransporter),hasbeenidentifiedasanimportantallergeninaquaticproducts.Thispaperaimstoexplorethecurrentresearchprogressonallergenichistidinekinaseinaquaticproducts,includingitsidentification,allergicreactions,andpossiblemitigationstrategies.Thefindingsinthispaperwillcontributetoenhancingtheunderstandingofallergenichistidinekinaseandfacilitatethedevelopmentofsaferandmoresustainableaquaticproducts. 1.Introduction Aquaticproductshavebeenacrucialpartofhumandiets,providinghigh-qualityprotein,vitamins,andessentialfattyacids.Despitetheirnutritionalvalue,theycanalsotriggerallergicreactionsinsusceptibleindividuals.Allergenichistidinekinase,aproteincomponentfoundinvariousaquaticproducts,hasbeenidentifiedasamajorallergenresponsibleforallergicreactions.Thispaperaimstosummarizethecurrentresearchprogressonallergenichistidinekinase,includingitsidentification,allergicreactions,andpotentialmitigationstrategies. 2.IdentificationofAllergenicHistidineKinase Varioustechniqueshavebeenemployedtoidentifyandcharacterizeallergenichistidinekinaseinaquaticproducts.Theseincludeimmunoassays,proteinseparationtechniques,andmolecularbiologymethods.Theuseofthesetechniqueshasenabledresearcherstoidentifyspecificproteinsthattriggerallergicreactionsinindividuals.Additionally,advancesinproteomicsandgenomicshavecontributedtotheidentificationandcharacterizationofallergenichistidinekinaseatthemolecularlevel. 3.AllergicReactionstoAllergenicHistidineKinase Allergicreactionstoallergenichistidinekinasecanrangefrommildsymptoms,suchasskinrashesanditching,tosevereanaphylacticreactions.Severalstudieshavereportedtheprevalenceofallergicreactionstofishandshellfish,

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