磷杂Fries重排反应用于合成2-芘基膦化合物（英文）-豆柴文库

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磷杂Fries重排反应用于合成2-芘基膦化合物（英文）
Title:ApplicationofPhosphorus-TetheredFriesRearrangementintheSynthesisof2-PhenylphosphineCompounds
Abstract:
ThePhosphorus-TetheredFriesRearrangementisanimportantsynthetictoolthatallowsforthesynthesisofvariousorganicphosphinecompounds.Thisreactioninvolvesthemigrationofanarylgroupfromoneatomofphosphorustoaneighboringatom,producingstructurallydiverseandversatile2-phenylphosphinederivatives.Thisarticleexplorestheapplications,mechanisms,andrecentadvancementsinthesynthesisof2-phenylphosphinecompoundsthroughthePhosphorus-TetheredFriesRearrangement.Itdiscussesthediversereactionconditions,reactionscope,andthepotentialutilityofthesecompoundsinvarioussyntheticandmedicinalchemistryapplications.
1.Introduction
1.1PhosphineCompounds:ImportanceandApplications
1.2OverviewofthePhosphorus-TetheredFriesRearrangement
2.MechanismandReactionScope
2.1MechanismofthePhosphorus-TetheredFriesRearrangement
2.2ReactiveSubstratesfortheRearrangement
2.3ElectrophilicandNucleophilicSubstitutionModes
3.ReactionConditionsandCatalysts
3.1SolventandTemperatureEffects
3.2TransferofCatalystsandLigands
3.3CatalystDesignandAdvancements
4.SyntheticApplicationsof2-PhenylphosphineCompounds
4.1Cross-CouplingReactionsandC-CBondFormation
4.2ChiralSynthesisandAsymmetricCatalysis
4.3MedicinalApplicationsandDrugDiscovery
5.RecentAdvancesandFuturePerspectives
5.1ExplorationofNewSubstratesandReactivity
5.2DevelopmentofNewCatalystsandLigands
5.3ApplicationsinMaterialScienceandNanotechnology
6.Conclusion
ThePhosphorus-TetheredFriesRearrangementisapowerfulsynthetictoolthathasbeenwidelyusedforthesynthesisof2-phenylphosphinecompounds.Thediversereactionconditions,reactionscope,andpotentialutilityinvariousapplicationsmakeitanexcitingareaofresearch.Theunderstandingofthereactionmechanismandthedevelopmentofnewcatalystsandligandswillfurtherexpanditssyntheticpossibilities.ThisarticleprovidesacomprehensiveoverviewofthePhosphorus-TetheredFriesRearrangement,highlightingitsimportanceandshowcasingrecentad