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含发酵产物类化妆品微生物检查方法适用性研究 Title:ResearchontheApplicabilityofMicrobiologicalExaminationMethodsforCosmeticsContainingFermentationProducts Abstract: Microbiologicalexaminationisacrucialstepinensuringthesafetyandqualityofcosmeticproducts.Cosmeticsthatcontainfermentationproductsaregainingpopularityduetotheirpotentialbenefitsfortheskin.However,theseproductsalsoposeuniquechallengesformicrobiologicaltesting.Thisstudyaimstoevaluateandcomparetheapplicabilityofvariousmicrobiologicalexaminationmethodsforcosmeticscontainingfermentationproducts.Theresultsprovideinsightsintothemostsuitablemethodsforensuringthemicrobiologicalsafetyoftheseproducts. Introduction: Cosmeticsformulatedwithfermentationproducts,suchasyeastextract,probiotics,andfermentedplantextracts,havegainedsignificantattentioninthebeautyandskincareindustry.Thefermentationprocessenhancesthebioavailabilityofactivecompounds,improvestexture,andincreasestheshelflifeofcosmetics.Asconsumerdemandfornaturalandsustainableproductsgrows,cosmeticswithfermentation-derivedingredientsarebeingutilizedmorefrequently. However,thepresenceoffermentationproductsincosmeticscreateschallengesfortraditionalmicrobiologicalexaminationmethods,astheseproductscancontainlivemicroorganismsortheirmetabolites.Microorganismpresenceandactivityresultingfromfermentationcanimpactproductstability,shelflife,andsafety.Therefore,itisessentialtodevelopsuitablemethodsforassessingthemicrobiologicalqualityofcosmeticscontainingfermentationproducts. Methods: Todeterminetheapplicabilityofvariousmicrobiologicalexaminationmethods,acomparativeanalysiswasconducted.Severalestablishedandcommonlyusedmethodswereevaluated,includingtotalviablecount(TVC),identificationofspecificmicroorganisms,preservativeefficacytesting,anddetectionofmetabolites.Avarietyofcommercialcosmeticscontainingfermentation-derivedingredientswereselectedforanalysis. Results: Thetotalviablecountmethodwasfoundtobeeffectiveinassessingtheoverallmicrobialloadofthecosmetics.However,italonedoesnotprovideinformationabo

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