高级病生动脉硬化讲座硕士班-豆柴文库

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会计学“Chronicinflammatorydisorderofintimaoflargebloodvesselscharacterisedbyformationoffibrofattyplaquescalledatheroma”.

Hardeningofarteries-ArteriosclerosisMacrophages
T-lymphocytes
AtherosclerosisLipidmetabolismimbalanceClassificationoflipidsandlipoproteinsCharacteristicsoflipoproteinsDigestionandmetabolismofdietaryfatHDLmetabolismandreversecholesteroltransportCholesteroleffluxandreversecholesteroltransportismodulatedbytworeceptorsPPARαactivatorsinducecholesteroleffluxandreversecholesteroltransportHDLmetabolism:5keygenesPPARα:apoA-l,apoA-ll,LPL,ABCA-1andSR-BIexpressionPPARaactivatorsinducecholesteroleffluxfromhumanmacrophagesCLA-1/SR-BIproteinmaypromotecholesterolremovalfromperipheralcellsCLA-1expressionisregulatedbyPPARαactivatorsindifferentiatedhumanmacrophagesPPARαactivatorsinducecholesteroleffluxandreversecholesteroltransportLDLTheearlylesion:modifiedlipoproteinsandfoamcellformationClassesofScavengerReceptorsTheScavengerReceptorFamilies
formodifiedLDL/ThemacrophageasaninflammatorymediatorStatinsinducePPARαactivityMacrophages
T-lymphocytes
InflammationRoleofmacrophagesTLRreceptorsandatherosclerosisImmuno-responseReducedatherosclerosisinMyD88nullmiceTLRsandatherosclerosis///WhydoesoxidizedLDLbecomeimmunogenic?/HowDoesImmunizationWithOxidizedLDLAffectAtherosclerosis?Isitpossibletoproduceavaccineagainstatherosclerosis?CharacterizationofepitopesinoxidizedLDLbyalibraryofpeptideELISAsActiveimmunizationofapoEnullmicewithapoB-100peptidesequencesEffectofoxidizedLDLpeptidevaccinesonatherosclerosisinmiceEffectofimmunizationwithMDA-apoB-100peptide45onspecificIgM,IgG,IgG1(Th2)andIgG2a(Th1)inapoEnullmiceImmunizationusingMDA-apoB-100peptidesinmicePassiveimmunizationstrategyEffectofpassiveimmunizationwithrecombinanthumanIgGagainstpeptide45onearlyatherosclerosisinmiceRegressionofaorticplaqueareainantibodytreatedApobec-1-/-/LDLr-/-miceRecombinanthumanantibodiestoMDA-apoB-100peptidesupregulateABCA-1expressioninvivoandinvitroRecombinanthumanantibodiestoMDA-apoB-100peptidesblockoxidi