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Thenewenglandjournalofmedicine

OriginalArticle

ARandomizedTrialofIntensiveversus
StandardBlood-PressureControl

TheSPRINTResearchGroup*

ABSTRACT

BACKGROUND
ThemostappropriatetargetsforsystolicbloodpressuretoreducecardiovascularThemembersofthewritingcommittee
morbidityandmortalityamongpersonswithoutdiabetesremainuncertain.(JacksonT.Wright,Jr.,M.D.,Ph.D.,Jeff
D.Williamson,M.D.,M.H.S.,PaulK.
METHODSWhelton,M.D.,JoniK.Snyder,R.N.,
B.S.N.,M.A.,KayceeM.Sink,M.D.,
Werandomlyassigned9361personswithasystolicbloodpressureof130mmHgM.A.S.,MichaelV.Rocco,M.D.,M.S.C.E.,
orhigherandanincreasedcardiovascularrisk,butwithoutdiabetes,toasystolicDavidM.Reboussin,Ph.D.,Mahboob
Rahman,M.D.,SuzanneOparil,M.D.,
blood-pressuretargetoflessthan120mmHg(intensivetreatment)oratargetofCoraE.Lewis,M.D.,M.S.P.H.,PaulL.
lessthan140mmHg(standardtreatment).TheprimarycompositeoutcomewasKimmel,M.D.,KarenC.Johnson,M.D.,
myocardialinfarction,otheracutecoronarysyndromes,stroke,heartfailure,orM.P.H.,DavidC.Goff,Jr.,M.D.,Ph.D.,
LawrenceJ.Fine,M.D.,Dr.P.H.,JeffreyA.
deathfromcardiovascularcauses.Cutler,M.D.,M.P.H.,WilliamC.Cush-
man,M.D.,AlfredK.Cheung,M.D.,and
RESULTSWalterT.Ambrosius,Ph.D.)assumere-
At1year,themeansystolicbloodpressurewas121.4mmHgintheintensive-sponsibilityfortheoverallcontentand
treatmentgroupand136.2mmHginthestandard-treatmentgroup.Theinterven-integrityofthearticle.Theaffiliationsof
themembersofthewritinggroupare
tionwasstoppedearlyafteramedianfollow-upof3.26yearsowingtoasignifi-listedintheAppendix.Addressreprint
cantlylowerrateoftheprimarycompositeoutcomeintheintensive-treatmentrequeststoDr.WrightattheDivisionof
groupthaninthestandard-treatmentgroup(1.65%peryearvs.2.19%peryear;NephrologyandHypertension,Universi-
tyHospitalsCaseMedicalCenter,Case
hazardratiowithintensivetreatment,0.75;95%confidenceinterval[CI],0.64toWesternReserveUniversity,1100Euclid
0.89;P<0.001).All-causemortalitywasalsosignificantlylowerintheintensive-Ave.Cleveland,OH44106-6053,orat
treatmentgroup(hazardratio,0.73