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MucinousCarcinomaoftheBreast:MRIFeaturesofPureandMixedFormswithHistopathologicCorrelation ShuichiMonzawaetalAJRMarch2009,VOLUME192NUMBER3Fig.1A—70-year-oldwomanwithpuremucinouscarcinoma.Coronalfat-saturatedT2-weightedMRimageshowshyperintensemass(arrow)withovalshapeandsmoothmargin.Fig.2—58year-oldwomanwithpuremucinouscarcinoma.Coronalfat-saturatedT2-weightedMRimageshowshyperintensemass(arrow)withirregularshapeandirregularmargin.Fig.3A—48-year-oldwomanwithlargepuremucinouscarcinoma.Coronalfat-saturatedT2-weightedMRimageshowshyperintensemass(arrow)withlobulatedshapeandirregularmargin.Darkinternalseptationsappearasisointenselinesinmass.Fig.3D—48-year-oldwomanwithlargepuremucinouscarcinoma.Photomicrographshowsmarkedproliferationoftumorcellswithmucincollection(grade3cellularity).Thickfibroussepta(arrows)areevidentbetweentumorcellclusters.(HandE,×1)Fig.4A—45-year-oldwomanwithpuremucinouscarcinoma.CoronalearlyphaseMRimageshowsirregularlyshapedmass(arrow)withstrongrimenhancement.Fig.5B—66-year-oldwomanwithmixedmucinouscarcinoma.CoronalearlyphaseMRimageshowsmass(arrow)withstrongheterogeneousenhancement.Fig.6C—37-year-oldwomanwithmixedmucinouscarcinoma.Photomicrographshowscomplextumorcomposedofnonmucinouscomponents(N)atperipheryandmucinouscomponents(M)(grade2cellularity)incenterofmass.(HandE,×1)Insummary,boththepureandmixedformsofmucinouscarcinomahadvariousshapes.Puretumorshadasmoothorirregularmargin,butallmixedtumorshadirregularmargins.Thepresenceofveryhighsignalintensityonfat-saturatedT2-weightedimageswasduetotheabundantaccumulationofmucusandwasacommonMRIfeatureinbothforms.Thisfindingmaybeadiagnosticcluesuggestingthepresenceofmucinouscarcinoma.Enhancementpatternduringtheearlyphasevariedwiththecellularityofpuretumorsandwiththedistributionofnonmucinouscomponentsinmixedtumors.HypocellularpuretumorshadatypicalpatternofgradualenhancementandcanbediagnosedcorrectlywithMRI.Hypercellularpuretumorshadstrongearlyenhancementandcanbedifficulttodifferentiatefrommixedtumors.Thepresenceofan
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